TABLE 1.
OS univariate analyses
| Predictor | Hazard ratio | 95% confidence interval | P-value | N | |
|---|---|---|---|---|---|
| T | |||||
| 1 | Reference | ||||
| 2 | 1.25 | 0.848 | 1.842 | .26 | |
| 3 | 2.663 | 1.626 | 4.361 | <.001 | |
| 4 | 2.568 | 1.661 | 3.97 | <.001 | 274 |
| N | |||||
| 0 | Reference | ||||
| 1 | 1.311 | 0.861 | 1.995 | .21 | |
| 2/3 | 3.065 | 2.170 | 4.329 | <.001 | 273 |
| AJCC stage | |||||
| I | Reference | ||||
| II | 1.262 | 0.766 | 2.08 | .36 | |
| III | 1.881 | 1.152 | 3.069 | .011 | |
| IV | 3.014 | 1.954 | 4.651 | <.001 | 273 |
| ECS | 3.022 | 2.088 | 4.376 | <.001 | 273 |
| CCI—age adjusted | 1.241 | 1.145 | 1.346 | <.001 | 274 |
| CCI | 1.281 | 1.158 | 1.416 | <.001 | 274 |
| Age | 1.017 | 1.005 | 1.03 | .006 | 274 |
| CAD | 1.649 | 1.152 | 2.359 | .006 | 274 |
| Adjuvant therapy | |||||
| None | Reference | ||||
| Post rad | 1.529 | 1.104 | 2.118 | .010 | |
| Post rad + post chemo | 1.615 | 0.977 | 2.67 | .062 | 269 |
| Pulmonary diagnosis | 1.431 | 1.056 | 1.938 | .021 | 272 |
| CVS | 1.833 | 1.059 | 3.174 | .030 | 273 |
| EtOH per week | 1.008 | 1 | 1.016 | .040 | 250 |
| Marital status | |||||
| Married | Reference | ||||
| Divorced/single/widowed | 1.352 | 1 | 1.828 | .05 | 273 |
| Complications | |||||
| No | Reference | ||||
| Yes | 1.353 | 0.957 | 1.915 | .09 | 274 |
| Smoke pack-years | 1.004 | 0.998 | 1.01 | .19 | 265 |
| Smoking status | |||||
| Never | Reference | ||||
| Current | 1.122 | 0.757 | 1.665 | .57 | |
| Past | 0.998 | 0.653 | 1.525 | .99 | 271 |
| Smoking status (pack-years) | |||||
| 10 pack years or less | Reference | ||||
| More than 10 pack years | 1.032 | 0.74 | 1.44 | .85 | 265 |
| EtOH consumption | |||||
| Never | Reference | ||||
| Current | 0.783 | 0.543 | 1.129 | .19 | |
| Past | 1.03 | 0.669 | 1.586 | .89 | 268 |
| EtOHism | 1.16 | 0.823 | 1.635 | .40 | 265 |
| HTN | 1.052 | 0.779 | 1.421 | .74 | 274 |
| Diabetes | 1.17 | 0.809 | 1.69 | .40 | 274 |
| Hypothyroidism | 0.905 | 0.548 | 1.494 | .70 | 273 |
| PVD | 1.044 | 0.648 | 1.683 | .86 | 273 |
| Hyperlipidemia | 0.95 | 0.637 | 1.417 | .80 | 273 |
| Obesity | 0.934 | 0.653 | 1.335 | .71 | 271 |
| Race | |||||
| White | Reference | ||||
| Other | 1.21 | 0.682 | 2.147 | .51 | 233 |
Abbreviations: CAD, coronary artery disease; CCI, Charlson Comorbidity Index; CVS, cerebrovascular stroke; ECS, extracapsular spread; ETOHism, defined by >14 drinks per week; HR, hazard ratio; HTN, hypertension; OS, overall survival; Post rad, adjuvant radiation therapy; PVD, peripheral vascular disease.