Table 4.
Swiss Target Report (prediction of GPCR’s, Caspases and ACE as targets for Iturin) and predicted Cyclin dependent kinases (CDK’s) through mapping against Iturin
| Target | Common name | Uniprot ID | ChEMBL ID | Target class |
|---|---|---|---|---|
| Acetylcholine receptor protein delta chain | CHRND | Q07001 | CHEMBL3011 | Ligand-gated ion channel |
| Acidic mammalian chitinase | CHIA | Q9BZP6 | CHEMBL1293197 | Enzyme |
| Acyl-CoA: Dihydroxyacetonephosphateacyltransferase | GNPAT | O15228 | CHEMBL4494 | Enzyme |
| Angiotensin-converting enzyme | ACE | P12821 | CHEMBL1808 | Protease |
| Apetite regulating hormone | GHRL | Q9UBU3 | CHEMBL1921664 | Unclassified protein |
| Baculoviral IAP repeat-containing protein 3 | BIRC3 | Q13489 | CHEMBL5335 | Enzyme |
| Beta secretase 2 | BACE2 | Q9Y5Z0 | CHEMBL2525 | Protease |
| Beta secretase 1 | BACE1 | P56817 | CHEMBL4822 | Protease |
| C-X-C chemokine receptor type 7 | ACKR3 | P25106 | CHEMBL2010631 | Family A G-protein coupled receptor |
| Calcitonin gene-related peptide type 1 receptor | CALCRL | Q16602 | CHEMBL3798 | Family B G-protein coupled receptor |
| Carboxypeptidase B2 isoform A | CPB2 | Q96IY4 | CHEMBL3419 | Protease |
| Carboxypeptidase N catalytic subunit | CPN1 | P15169 | CHEMBL4713 | Protease |
| Caspase-1 | CASP1 | P29466 | CHEMBL4801 | Protease |
| Caspase-2 | CASP2 | P42575 | CHEMBL4884 | Protease |
| Cyclin-dependent kinase 4/cycline D1 | CCND1 | P24385 | CHEMBL1907601 | Kinase |
| CDK4 | P11802 | |||
| CDK2/Cyclin A CCNA2 | CDK2 | P20248 | CHEMBL3038469 | Kinase |
| P24941 | ||||
| Histone deacetylase 8 | HDAC8 | Q9BY41 | CHEMBL3192 | Eraser |
| Chymotrypsin C | CTRC | Q99895 | CHEMBL2386 | Protease |
| Signal transducer and activator of transcription 6 | STAT6 | P42226 | CHEMBL5401 | Transcription factor |
| Melanocortin receptor 5 | MC5R | P33032 | CHEMBL4608 | Family A G-protein coupled receptor |
| E3 SUMO-protein ligase | CBX4 | O00257 | CHEMBL3232685 | Enzyme |
| Ceramide glucosyltransferase | UGCG | Q16739 | CHEMBL2063 | Family A G-protein coupled receptor |
| Neurokine 1 receptor | TACR1 | P25103 | CHEMBL249 | Family A G-protein coupled receptor |
| Cholecystokin B receptor | CCKBR | P32239 | CHEMBL298 | Family A G-protein coupled receptor |
| Interleukin-1 beta | IL1B | P01584 | CHEMBL1909490 | Secreted protein |
| Proteinase-activated receptor 1 | F2R | P25116 | CHEMBL3974 | Family A G-protein coupled receptor |