Table 2.
Univariate analysis for DFS and OS variables, hazard ratio and 95% confidence interval.
| DFS |
OS |
|||||
|---|---|---|---|---|---|---|
| Variable | # Events | HR (95% CI) | p value | # Events | HR (95% CI) | p value |
| Age Group | 0.098 | 0.07 | ||||
| ≤50 (N = 77) | 43 | ref | 32 | ref | ||
| >50 (N = 116) | 47 | 0.7 (0.46, 1.07) | 58 | 1.51 (0.97, 2.34) | ||
| Sex | 0.08 | 0.68 | ||||
| Female (N = 105) | 56 | ref | 54 | ref | ||
| Male (N = 88) | 34 | 0.68 (0.44, 1.04) | 36 | 0.91 (0.59, 1.41) | ||
| Race | 0.25 | 0.40 | ||||
| Black (N = 24) | 14 | ref | 12 | ref | ||
| White (N = 164) | 76 | 0.71 (0.4, 1.26) | 78 | 0.77 (0.42, 1.42) | ||
| Smoking | 0.61 | 0.45 | ||||
| Never (n = 71) | 32 | ref | 29 | ref | ||
| Past (N = 80) | 42 | 1.08 (0.68, 1.71) | 43 | 1.35 (0.84, 2.18) | ||
| Current (N = 29) | 7 | 0.72 (0.31, 1.63) | 7 | 1.34 (0.57, 3.13) | ||
| LVI | 0.02 | 0.15 | ||||
| No (N = 140) | 61 | ref | 64 | ref | ||
| Yes (N = 43) | 25 | 1.73 (1.08, 2.76) | 20 | 1.45 (0.87, 2.41) | ||
| PNI | <0.001 | 0.006 | ||||
| No (N = 56) | 22 | ref | 28 | ref | ||
| Yes (N = 130) | 66 | 2.45 (1.47, 4.08) | 59 | 2.0 (1.23, 3.25) | ||
| Node Status | 0.36 | 0.009 | ||||
| N0 (N = 169) | 80 | ref | 78 | ref | ||
| N1+ (N = 16) | 8 | 1.41 (0.68, 2.93) | 10 | 2.44 (1.25, 4.77) | ||
| Resection Margin | <0.001 | <0.001 | ||||
| Negative (N = 82) | 32 | ref | 34 | ref | ||
| Positive (N = 105) | 56 | 2.39 (1.5, 3.82) | 53 | 2.18 (1.38, 3.43) | ||
| Gland Type | 0.89 | 0.08 | ||||
| Major (N = 80) | 39 | ref | 36 | ref | ||
| Minor (N = 111) | 50 | 1.03 (0.67, 1.57) | 54 | 1.48 (0.96, 2.28) | ||
| T Stage | <0.001 | <0.001 | ||||
| 1–3 (N = 121) | 52 | ref | 48 | ref | ||
| 4 (N = 64) | 35 | 2.29 (1.46, 3.6) | 37 | 3.56 (2.24, 5.66) | ||
| N Stage | 0.49 | 0.009 | ||||
| 0 (N = 174) | 80 | ref | 79 | ref | ||
| 1 (N = 9) | 5 | 1.28 (0.52, 3.16) | 6 | 1.94 (0.84, 4.49) | ||
| 2 (N = 7) | 3 | 1.92 (0.6, 6.11) | 4 | 4.2 (1.51, 11.7) | ||
| Overall Stage | 0.006 | <0.001 | ||||
| 1 (N = 54) | 19 | ref | 20 | ref | ||
| 2 (N = 41) | 21 | 1.35 (0.71, 2.58) | 17 | 1.12 (0.58, 2.16) | ||
| 3 (N = 26) | 12 | 1.43 (0.69, 2.98) | 11 | 1.7 (0.8, 3.63) | ||
| 4 (N = 63) | 35 | 2.64 (1.49, 4.67) | 37 | 3.98 (2,0.22, 7.12) | ||
| Pathologic Grade | 0.01 | 0.02 | ||||
| 1 (N = 52) | 17 | ref | 17 | ref | ||
| 2 (N = 29) | 12 | 1.61 (0.76, 3.41) | 8 | 1.24 (0.53, 2.92) | ||
| 3 (N = 30) | 19 | 2.78 (1.42, 5.43) | 19 | 2.48 (1.27, 4.85) | ||
| Sinonasal | 0.01 | 0.005 | ||||
| No (N = 143) | 60 | ref | 60 | ref | ||
| Yes (N = 50) | 30 | 1.79 (1.14, 2.8) | 30 | 1.93 (1.22, 3.04) | ||
| Adjuvant Therapy | 0.74 | 0.74 | ||||
| None (N = 63) | 27 | ref | 33 | ref | ||
| Radiation (N = 117) | 58 | 1.2 (0.76, 1.91) | 53 | 1.11 (0.71, 1.73) | ||
| Chemoradiation (N = 12) | 5 | 1.14 (0.43, 2.96) | 4 | 0.76 (0.27, 2.17) | ||
| Diabetes | 0.04 | 0.75 | ||||
| No (N = 173) | 85 | ref | 82 | ref | ||
| Yes (N = 20) | 5 | 0.4 (0.16, 0.98) | 8 | 0.89 (0.43, 1.85) | ||
| Metformin | 0.03 | 0.89 | ||||
| No (N = 177) | 87 | ref | 83 | ref | ||
| Yes (N = 16) | 3 | 0.29 (0.09, 0.91) | 7 | 0.95 (0.44, 2.05) | ||
| CAD | 0.35 | 0.47 | ||||
| No (N = 164) | 76 | ref | 75 | ref | ||
| Yes (N = 29) | 14 | 1.32 (0.74, 2.35) | 15 | 1.24 (0.69, 2.21) | ||
| Hx MI | 0.007 | 0.002 | ||||
| No (N = 189) | 86 | ref | 86 | ref | ||
| Yes (N = 4) | 4 | 4.07 (1.47, 11.3) | 4 | 5.09 (1.82, 14.19) | ||
| HLD | 0.13 | 0.86 | ||||
| No (N = 141) | 74 | ref | 71 | ref | ||
| Yes (N = 52) | 16 | 0.65 (0.38, 1.13) | 19 | 1.05 (0.62, 1.77) | ||
| HTN | 0.18 | 0.94 | ||||
| No (N = 114) | 58 | ref | 54 | ref | ||
| Yes (N = 79) | 32 | 0.74 (0.48, 1.15) | 36 | 1.02 (0.66, 1.57) | ||
| Obesity | 0.71 | 0.51 | ||||
| No (N = 173) | 81 | ref | 85 | ref | ||
| Yes (N = 20) | 9 | 1.14 (0.57, 2.28) | 5 | 0.74 (0.3, 1.82) | ||
| COPD | 0.94 | |||||
| No (N = 168) | 75 | ref | 0.4 | 77 | ref | |
| Yes (N = 25) | 15 | 1.28 (0.72, 2.27) | 13 | 1.02 (0.56, 1.86) | ||