TABLE 1.
Pharmacokinetic parameters of AMB after administration of ABLC at 5 mg/kg/day to 17 patients with proven or suspected fungal infections
| Parameterb | Valuea after:
|
|
|---|---|---|
| First dose | Last dose | |
| Cmax (μg/ml) | 3.67 ± 2.37 | 2.39 ± 1.58 |
| Tmax (h) | 2.24 ± 1.12 | 1.58 ± 0.56 |
| AUC0–24 (μg · h/ml) | 16.45 ± 7.22 | 19.17 ± 4.43 |
| AUC0–∞ (μg · h/ml) | 241.29 ± 122.93 | |
| CL (liters/h) | 17.8 ± 5.2 | |
| Varea (liters) | 9,301 ± 8,384 | |
| Vss (liters) | 865 ± 347 | |
| T1/2 (h) | 393 ± 486 | |
a
Values are means ± SD.
b
Tmax, time to maximum concentration of AMB; AUC0–∞, AUC from 0 h to ∞; CL, clearance; Vss, volume of distribution at steady state; T1/2, elimination half-life.