Table 2.
Association of First Admission Clinical Parameters with Abnormal Liver Function of T3 and T4 Stage
| Variables | T3 Stage | T4 Stage | ||||||
|---|---|---|---|---|---|---|---|---|
| Univariate★ OR (95% CI) | P values | Multivariate★ OR (95% CI) | P values | Univariate★ OR (95% CI) | P values | Multivariate★ OR (95% CI) | P values | |
| BMI (kg/m2) | 1.730 (1.176, 2.546) | 0.005 | 1.649 (1.059, 2.568) | 0.027 | 0.967 (0.578, 1.617) | 0.898 | ||
| ALT (U/L) | 1.785 (1.205, 2.645) | 0.004 | 1.349 (0.791, 2.300) | 0.272 | 1.807 (0.979, 3.334) | 0.058 | 2.041 (1.170, 3.561) | 0.012 |
| AST (U/L) | 1.358 (0.949, 1.943) | 0.094 | 0.866 (0.482, 1.557) | 0.631 | 1.511 (0.899, 2.542) | 0.119 | ||
| ALP (U/L) | 1.156 (0.818, 1.635) | 0.411 | 1.201 (0.715, 2.019) | 0.489 | ||||
| GGT (U/L) | 1.827 (1.224, 2.729) | 0.003 | 1.983 (1.282, 3.066) | 0.002 | 1.091 (0.634, 1.879) | 0.752 | ||
| TB (μmol/L) | 1.095 (0.776, 1.545) | 0.696 | 1.115 (0.674, 1.844) | 0.672 | ||||
| TP (g/L) | 1.073 (0.758, 1.518) | 0.692 | 1.057 (0.644, 1.737) | 0.826 | ||||
| ALB (g/L) | 1.250 (0.856, 1.827) | 0.249 | 1.352 (0.780, 2.343) | 0.283 | ||||
| Crea (μmol/L) | 0.875 (0.557, 1.374) | 0.562 | 1.008 (0.499, 2.036) | 0.982 | ||||
| BUN (mmol/L) | 0.872 (0.601, 1.267) | 0.474 | 0.729 (0.416, 1.278) | 0.270 | ||||
| UA (μmol/L) | 1.048 (0.727, 1.510) | 0.802 | 0.936 (0.557, 1.575) | 0.805 | ||||
| GLU (mmol/L) | 0.927 (0.648, 1.326) | 0.679 | 1.084 (0.659, 1.783) | 0.751 | ||||
| TG (mmol/L) | 1.108 (0.780, 1.574) | 0.566 | 0.588 (0.337, 1.025) | 0.061 | 0.585 (0.336, 1.019) | 0.059 | ||
| TC (mmol/L) | 1.030 (0.730, 1.454) | 0.864 | 1.324 (0.803, 2.813) | 0.272 | ||||
| HDL-C (mmol/L) | 0.874 (0.618, 1.236) | 0.446 | 1.189 (0.725, 1.950) | 0.493 | ||||
| LDL-C (mmol/L) | 1.023 (0.724, 1.445) | 0.899 | 1.296 (0.788, 2.132) | 0.307 | ||||
| IgG (g/L) | 0.896 (0.627, 1.280) | 0.547 | 0.779 (0.461, 1.318) | 0.352 | ||||
| IgA (g/L) | 0.852 (0.595, 1.219) | 0.380 | 0.937 (0.544, 1.616) | 0.815 | ||||
| IgM (g/L) | 0.832 (0.559, 1.238) | 0.364 | 1.018 (0.536, 1.931) | 0.957 | ||||
| C3 (g/L) | 1.363 (0.937, 1.981) | 0.105 | 1.042 (0.625, 1.738) | 0.873 | ||||
| C4 (g/L) | 1.155 (0.806, 1.655) | 0.433 | 1.020 (0.607, 1.714) | 0.941 | ||||
| C1Q (mg/L) | 0.968 (0.675, 1.389) | 0.860 | 1.120 (0.653, 1.920) | 0.681 | ||||
| ASO (KIU/L) | 1.110 (0.773, 1.594) | 0.570 | 0.851 (0.497, 1.455) | 0.555 | ||||
| CRP (mg/L) | 1.034 (0.720, 1.484) | 0.858 | 1.172 (0.683, 2.010) | 0.565 | ||||
| WBC (×109/L) | 0.977 (0.694, 1.375) | 0.893 | 0.753 (0.455, 1.248) | 0.271 | ||||
| Neutrophil count (×109/L) | 0.953 (0.674, 1.349) | 0.787 | 0.756 (0.453, 1.261) | 0.284 | ||||
| Lymphocyte count (×109/L) | 1.213 (0.849, 1.733) | 0.288 | 0.757 (0.446, 1.283) | 0.300 | ||||
| Monocyte coun (×109/L) | 0.985 (0.693, 1.400) | 0.932 | 1.334 (0.802, 2.219) | 0.267 | ||||
| Neutrophil ratio (%) | 0.823 (0.578, 1.173) | 0.282 | 1.009 (0.606, 1.681) | 0.973 | ||||
| Lymphocyte ratio (%) | 1.192 (0.831, 1.709) | 0.340 | 0.937 (0.548, 1.604) | 0.813 | ||||
| Monocyte ratio (%) | 1.080 (0.760, 1.536) | 0.667 | 1.504 (0.900, 2.612) | 0.119 | ||||
| RBC (×1012/L) | 1.344 (0.879, 2.056) | 0.172 | 1.013 (0.567, 1.810) | 0.966 | ||||
| HB (g/L) | 1.428 (0.916, 2.228) | 0.116 | 1.023 (0.565, 1.854) | 0.939 | ||||
| PLT (×109/L) | 0.850 (0.600, 1.202) | 0.358 | 0.867 (0.525, 1.433) | 0.578 | ||||
| IL-2 (pg/mL) | 0.716 (0.501, 1.024) | 0.067 | 0.636 (0.423, 0.955) | 0.029 | 1.103 (0.662, 1.837) | 0.706 | ||
| IL-4 (pg/mL) | 0.832 (0.590, 1.172) | 0.292 | 0.998 (0.597, 1.666) | 0.993 | ||||
| IL-6 (pg/mL) | 1.231 (0.865, 1.752) | 0.249 | 1.103 (0.662, 1.839) | 0.706 | ||||
| IL-10 (pg/mL) | 1.038 (0.736, 1.465) | 0.830 | 1.147 (0.697, 1.887) | 0.589 | ||||
| TNF-α (pg/mL) | 0.777 (0.547, 1.104) | 0.159 | 1.115 (0.668, 1.861) | 0.678 | ||||
| IFN-γ (pg/mL) | 0.867 (0.612, 1.228) | 0.421 | 0.924 (0.561, 1.522) | 0.757 | ||||
| Percentage of CD4+ T cells (%) | 1.027 (0.726, 1.453) | 0.879 | 1.330 (0.800, 2.210) | 0.271 | ||||
| Percentage of CD8+ T cells (%) | 1.472 (1.023, 2.118) | 0.037 | 1.727 (1.118, 2.667) | 0.014 | 1.032 (0.610, 1.745) | 0.906 | ||
| Percentage of CD3+ T cells (%) | 1.147 (0.804, 1.635) | 0.449 | 1.342 (0.783, 2.297) | 0.284 | ||||
Abbreviations: ALT, Alanine aminotransferase; AST, Aspartate aminotransferase; ALP, Alkaline phosphatase; GGT, γ-glutamyl transpeptidase; TB, Total bilirubin; TP, Total protein; ALB, Albumin; Crea, Creatinine; BUN, Blood urea nitrogen; UA, Uric acid; GLU, Glucose; TG, Triglyceride; TC, Total cholesterol; HDL-C, High density lipoprotein cholesterol; LDL-C, Low density lipoprotein cholesterol; IgG, Immunoglobulin G; IgA, Immunoglobulin A; IgM, Immunoglobulin M; C3, Complement C3; C4, Complement C4; C1q, Complement C1q; ASO, Anti streptolysin O; CRP, C-reactive protein; WBC, White blood cell count; N, Neutrophil count; L, Lymphocyte count; M, Monocyte count; NR, Neutrophil ratio; LR, Lymphocyte ratio; MR, Monocyte ratio; RBC, Red blood cell count; Hb, Hemoglobin; PLT, Platelet; IL-2, Interleukin-2; IL-4, Interleukin-4; IL-6, Interleukin-6; IL-10, Interleukin-10; TNF-α, Tumor necrosis factor-α; IFN-γ, Interferon-γ; ★, Adjusted by age and gender. OR, odds ratio; CI, confidence interval.