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. 2022 Apr 5;13:863451. doi: 10.3389/fphar.2022.863451

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Copyright © 2022 Wang, Liu, Yang, Sun, Wang, Sui, Yang, Wang, Song, Zhang, Xiao, Wang, Wang and Luo.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The target proteins of meldonium are related to the metabolic pathway as revealed using the human proteome microarray analysis. (A) Schematic of the procedure used to detect biotin-meldonium binding proteins. (B) Venn map of the positive spots for meldonium and biotin target proteins. The number in the yellow area represents the number of meldonium-specific target proteins. MD: meldonium. (C) Top 20 enriched pathways of meldonium target proteins. (D) Top 20 enriched cellular components of meldonium target proteins. (E) Top 20 enriched biological processes of meldonium target proteins. (F) Top 20 enriched molecular functions of meldonium target proteins.