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. 2022 Apr 5;13:863451. doi: 10.3389/fphar.2022.863451

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Copyright © 2022 Wang, Liu, Yang, Sun, Wang, Sui, Yang, Wang, Song, Zhang, Xiao, Wang, Wang and Luo.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Meldonium regulates glycolytic enzymes and pyruvate metabolism in vivo and in vitro. (A) Representative spots of meldonium target proteins, including the glycolytic process. MD: meldonium. (B) mRNA expression of PFKP, PKM2, LDHA, and PDK1 in RLE-6TN cells (n = 4–5). (C) Protein expression of PFKP, PKM2, LDHA, PDH, and PDK1 in RLE-6TN cells (n = 4). (D) Protein expression of PFKP, PKM2, LDHA, and PDK1 in lungs of mice after hypoxia for 24 h (n = 6–7). Data are expressed as the mean ± SEM. Statistical analyses were performed using one-way ANOVA followed by Fisher’s LSD test. #p < 0.05, ##p < 0.01, ###p < 0.001 compared with the control group; *p < 0.05, **p < 0.01 compared with the hypoxia group.