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. 2021 Dec 10;25(4):307–318. doi: 10.1093/ijnp/pyab089

Figure 2.

Figure 2.

Behavioral effects of the coadministration of fluoxetine (FLX) (10 mg/kg) alone (n = 8) or in combination with Galanin(1-15) [GAL(1-15)] (1 nmol) (n = 7) or GAL(1-15) (1 nmol)+M871 (3 nmol) (n = 9) in the forced swimming test (FST). FLX was administered s.c. 23, 5 and 1 hour before the test. Cerebrospinal fluid, GAL(1-15), or GAL(1-15) (1 nmol)+M871 (3 nmol) was injected i.c.v. 15 minutes before the test. Vertical bars represent the mean ± SEM of the immobility (A) or swimming time (B) during the 5-minute test period. In (A) *P < .05, ***P < .001 vs sham (n = 7) and OBX-saline groups (n = 6); #P < .05 vs OBX-Flx (10 mg/kg)+Gal(1-15) (1 nmol); in (B) ***P < .001 vs rest of the groups according to 1-way ANOVA followed by Fisher’s least significance difference test.