Table 1.

Effects of FLX (10 mg/kg) alone or in combination with GAL(1-15) (1 nmol) on the specific [³⁵S]GTPγS binding in the DG and CA1 of the Hippocampus

		Basal values nCi/g tissue	Net stimulation induced by 10 μM 8-OH-DPAT (nCi/g tissue)
DG	Sham	2.12 ± 0.14	0.37 ± 0.07
	OBX saline	2.18 ± 0.12	0.29 ± 0.04
	OBX FLX (10 mg)	1.32 ± 0.1***	0.48 ± 0.1
	OBX FLX (10 mg)+Gal(1-15) (1 nmol)	1.35 ± 0.08***	0.37 ± 0.13
CA1	Sham	1.84 ± 0.17	0.43 ± 0.01
	OBX saline	2.15 ± 1.14	0.68 ± 0.17
	OBX FLX (10 mg)	1.41 ± 0.12	0.43 ± 0.11
	OBX FLX (10 mg)+Gal(1-15) (1 nmol)	1.5 ± 0.11a	0.42 ± 0.13

Abbreviations: 8-OH-DPAT, 8-hydroxy-2-(di-n-propylamino)tetralin; FLX, fluoxetine; GAL(1-15), Galanin(1-15); OBX, olfactory bulbectomy rat.

Data are represented as mean ± SEM of the basal binding and the net 8-OH-DPAT stimulated [³⁵S]GTPγS binding (n = 6). *P < .05, ***P < .001 vs sham and OBX-saline groups.

^a P < .01 vs OBX-saline group according to 1-way ANOVA followed by Fisher’s least significance difference test.