Figure 2.

Skeletal muscle mitochondrial respiratory function from healthy controls (Con, n = 11) and patients with peripheral artery disease (PAD, n = 10). A: state 3 respiratory function (pmol·s⁻¹·mg⁻¹) was attenuated in PAD compared with Con at complex I (CI, P < 0.01), complex I + II (CI + II, P < 0.01), and complex II (CII, P < 0.01). State 4 respiration and complex IV (CIV) respiration (pmol·s⁻¹·mg⁻¹) were not different between Con and PAD (P = 0.59 and 0.21, respectively). B: respiratory control ratio (RCR, CI + II state 3/state 4 respiration) was lower in PAD compared with Con (P < 0.01). Data are means ± SD. †P < 0.01 vs. Con.