Figure 5.

Measurements of in vivo skeletal muscle microvascular oxygenation capacity in healthy controls (Con, n = 5) and patients with peripheral artery disease (PAD, n = 6) for tissue oxygenation index (TOI) and relationships with flow-mediated vasodilation (30 μL·min⁻¹), acetylcholine (ACh)-mediated dilation (10⁻³ M), and skeletal muscle oxidative phosphorylating respiration (CI + II state 3 respiration). A: the slope of TOI recovery (%·s⁻¹) was attenuated in PAD compared with Con (P = 0.04). B: positive relationship (r = 0.8, P < 0.01) between flow-mediated vasodilation (%) and slope of TOI recovery rate (%·s⁻¹). C: positive relationship (r = 0.5, P = 0.10) between maximal ACh-mediated vasodilation (%) and slope of TOI recovery rate (%·s⁻¹). D: positive relationship (r = 0.7, P = 0.03) between CI + II state 3 respiration (pmol·s⁻¹·mg⁻¹) and slope of TOI recovery rate (%·s⁻¹). Data are means ± SD. *P < 0.05 vs. Con.