Figure 2.

Vascular conductance pre (A and B)- and post (C and D)-salsalate administration in healthy nondepressed adults (HAs, n = 10 total, n = 5 female) and in those with major depressive disorder (MDD, n = 13 total, n = 6 female). Data are presented in response to increased doses of acetylcholine (ACh) alone [control (Con)] and during concurrent nitric oxide synthase inhibition [N^G-nitro-l-arginine methyl ester (l-NAME)] in A and C and as areas under the dose-response curve in B and D. When compared with HA, endothelium-dependent dilation was blunted in adults with MDD before (A and B), but not after (C and D), short-term salsalate administration. B, baseline. Data are means ± SD (${\mathrm{\eta }}_{\text{p}}^2$) and were analyzed using three-way, mixed-model, repeated-measures analysis of covariance. *P < 0.05 vs. HA; †P < 0.05 vs. Con.