Figure 4.
Vascular conductance pre (A)- and post (B)-salsalate administration in adults with major depressive disorder (MDD, n = 7 total, n = 3 women). Data are presented in response to increased doses of acetylcholine (ACh) alone [control (Con)] and during concurrent nitric oxide synthase inhibition [NG-nitro-l-arginine methyl ester (l-NAME)], NADPH oxidase inhibition with apocynin (Apo), or both (Apo + l-NAME) in A and B and as areas under the dose-response curve in C. Before salsalate treatment, acute administration of Apo improved ACh-induced dilation via increases in the NO-dependent contribution of the response. Following short-term salsalate treatment, Apo-induced improvements in ACh-induced dilation were no longer evident. B, baseline. Data are means ± SD (ηp2) and were analyzed using three-way, mixed-model, repeated-measures analysis of covariance. *P < 0.05 vs. Con.