Table 2.

Circulating proinflammatory markers before and after salsalate treatment

	HA		MDD		Group (${\mathrm{\eta }}_{\text{p}}^2$)	Condition (${\mathrm{\eta }}_{\text{p}}^2$)	Sex (${\mathrm{\eta }}_{\text{p}}^2$)	Group × Condition (${\mathrm{\eta }}_{\text{p}}^2$)
	Pre	Post	Pre	Post
CRP, mg/L	0.7 ± 0.3 [0.2–2.5]	1.8 ± 0.6 [0.2–3.8]	2.0 ± 1.3 [0.2–12.1]	0.7 ± 0.2 [0.2–2.1]	0.19 (0.15)	0.06 (0.28)	0.93 (<0.01)	0.06 (0.30)
IL-1β, pg/mL	0.06 ± 0.07 [0–0.18]	0.08 ± 0.08 [0–0.22]	0.12 ± 0.13 [0–0.4]	0.11 ± 0.16 [0–0.56]	0.18 (0.08)	0.88 (<0.01)	0.715 (0.10)	0.76 (<0.01)
IL-6, pg/mL	0.52 ± 0.41 [0.16–1.70]	0.66 ± 0.65 [0.10–1.84]	0.51 ± 0.23 [0.18–1.16]	0.36 ± 0.16 [0.14–0.70]	0.20 (0.08)	0.95 (0.0)	0.44 (0.03)	0.22 (0.07)
IL-8, pg/mL	3.37 ± 0.98 [2.22–5.56]	3.90 ± 0.1.93 [2.18–6.46]	4.00 ± 1.24 [1.64–9.24]	4.25 ± 1.52 [1.90–7.34]	0.47 (0.03)	0.14 (0.11)	0.07 (0.15)	0.74 (<0.01)
TNFα, pg/mL	1.82 ± 0.54 [0.98–2.74]	2.04 ± 0.60 [1.30–3.26]	2.05 ± 0.47 [1.40–2.74]	2.06 ± 0.60 [1.18–3.04]	0.48 (0.03)	0.32 (0.05)	0.95 (0.0)	0.47 (0.03)

Values are means ± SD [ranges]. Data were analyzed using three-way, mixed-model, repeated-measures analysis of covariance; n = 10 HAs (5 women), and n = 13 MDD (6 women). CRP, C-reactive protein; HA, healthy nondepressed adult; IL, interleukin; MDD, major depressive disorder; TNF, tumor necrosis factor.