Figure 3. Weighted co-expression network analysis.

(A) Network visualization of seven gene co-expression communities identified. Nodes and node size represent genes and their centrality (degree) respectively and edges represent significant Spearman correlation (adj p < 0.001 and R > 84). Key significantly regulated pathways (adj. p < 0.05) in each community are labeled. (B) Heatmap of correlations among top 5% central genes in each community. Column and row annotation denotes corresponding communities. (C) Heatmap of significant correlation (adj. p < 0.05) between key metabolic and signaling pathways mentioned in (A). Column and row annotation denotes corresponding pathways.

Figure 3—figure supplement 1. Gene set enrichment analysis of the individual communities.

Figure 3—figure supplement 2. Weight co-expression network of the negatively co-related genes We observed a high number of negative correlations between this community (c1) and those associated with Notch, mTOR, and FoxO signaling (c5) and HIF-1 signaling (c7).