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. 2022 Apr 6;20:1691–1701. doi: 10.1016/j.csbj.2022.04.004

Fig. 1.

Fig. 1

Identification and characterization of stemness subtypes of LUAD in bulk tumors. A. Hierarchical clustering identifying three stemness subtypes: St-H, St-M, and St-L, consistent in five different datasets, based on the enrichment scores of 12 stemness gene sets. B. Comparison of the enrichment scores of a stemness signature composed of 109 genes [1] among the stemness subtypes of LUAD. C. Kaplan–Meier curves showing that St-H and St-L likely have the best and worst 5-year overall survival (OS) and/or disease-free survival (DFS) prognosis, respectively. D. Comparisons of tumor purity among the stemness subtypes. Comparisons of proportion of late-stage tumors (E), mutation rates of TP53 and EGFR (F), and proportion of smokers (G) between St-H and St-L. (H) Comparisons of the enrichment scores of five biological processes in TCGA-LUAD. (I) Pseudotime analysis showing the trajectory paths of the stemness subtypes in TCGA-LUAD. The one-tailed Mann–Whitney U test (B), log-rank test (C), Kruskal–Wallis test (D, H), and Z test (E, F, G) P-values are shown. * P < 0.05, ** P < 0.01, *** P < 0.001, ns not significant.