Fig. 6.

Characterization of immune and clinical features of the stemness subtypes of LUAD single cells in LUAD-scRNA. A. Clustering all single cells in LUAD-scRNA by t-SNE [28]. Comparisons of the expression of immune signatures (B) and the ratios of immunostimulatory over immunosuppressive signatures (C) among the stemness subtypes of LUAD single cells. Comparisons of the proportions of high-stemness cells between late-stage and early-stage LUAD patients (D) and between progressive and regressive or stable LUAD patients (E). The one-tailed Mann–Whitney U test (B, D, E), two-tailed Student’s t test (B), and one-way ANOVA test P-values (B, C) are shown. *** P < 0.001.