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Proposed Model for Role of Phospho-Cav-1 as a Regulator of Mitochondrial Fission/Fusion Dynamics and Mitophagy. Cav-1 associates with Mfn2 and thereby reduces the recruitment of Mfn2 to mitochondria. Simultaneously, Cav-1 also interacts with Drp1 and inhibits its mitochondrial targeting. Depletion or dephosphorylation of Cav-1 releases Mfn2 and Drp1 which translocate to mitochondria, increasing both fusion and fission of mitochondria, and also facilitate initiation of mitophagy.
