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. 2022 Apr 12;2022:3156245. doi: 10.1155/2022/3156245

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Copyright © 2022 Zhefeng Chen et al.

This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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In vivo cartilage regeneration in nude mice. (a) Gross morphology examination after hydrogels were injected subcutaneously into nude mice for 4 weeks. (b) Implants containing Kindlin-2 overexpression or knockdown chondrocytes cocultured with BMSCs were analyzed by wet weight. Values are expressed as mean ± s.d., ^∗p < 0.05, ^∗∗∗p < 0.001, ns indicates no significance. (c) Implants containing Kindlin-2 overexpression or knockdown chondrocytes cocultured with BMSCs were analyzed by Safranin O, Masson, collagen I, and collagen II staining confirmed by histological examination and immunohistochemical staining.