Table 3.
Individual centrality of DN (2016-2020).
| Rank | Major MeSH terms/MeSH subheadings | Degree | Betweenness | Closeness | Rank | Major MeSH terms/MeSH subheadings | Degree | Betweenness | Closeness |
|---|---|---|---|---|---|---|---|---|---|
| 1 | Diabetic Nephropathies/drug therapy | 1167 | 35.64902878 | 61 | 29 | Oxidative Stress/drug effects | 206 | 7.044936657 | 79 |
| 2 | Diabetic Nephropathies/metabolism | 898 | 27.9265995 | 63 | 30 | Diabetes Mellitus, Type 2/physiopathology | 160 | 8.698302269 | 76 |
| 3 | Diabetes Mellitus, Type 2/complications | 1046 | 35.63362122 | 61 | 31 | Sodium-Glucose Transporter 2 Inhibitors/therapeutic use | 248 | 6.357406139 | 82 |
| 4 | Diabetic Nephropathies/genetics | 458 | 26.97906876 | 64 | 32 | Diabetes Mellitus, Type 2 / genetics | 142 | 3.724227667 | 86 |
| 5 | Diabetic Nephropathies/prevention & control | 626 | 35.073246 | 60 | 33 | MicroRNAs/metabolism | 166 | 6.197879791 | 79 |
| 6 | Diabetes Mellitus, Type 2/drug therapy | 714 | 26.34806252 | 66 | 34 | Diabetes Mellitus, Type 2/metabolism | 174 | 16.12250137 | 69 |
| 7 | Diabetic Nephropathies/diagnosis | 562 | 29.09814835 | 64 | 35 | MicroRNAs/genetics | 128 | 6.311041355 | 82 |
| 8 | Diabetic Nephropathies/pathology | 466 | 33.63822937 | 60 | 36 | Podocytes/pathology | 146 | 3.63256979 | 82 |
| 9 | Diabetic Nephropathies/etiology | 491 | 46.17017365 | 57 | 37 | Hypoglycemic Agents/pharmacology | 170 | 6.250207901 | 82 |
| 10 | Diabetic Nephropathies/epidemiology | 393 | 11.70644283 | 74 | 38 | Diabetes Mellitus | 99 | 3.609862089 | 92 |
| 11 | Diabetic Nephropathies/physiopathology | 334 | 22.46341896 | 64 | 39 | Signal Transduction/drug effects | 133 | 2.63280654 | 83 |
| 12 | Diabetic Nephropathies/blood | 325 | 14.88596535 | 71 | 40 | Renal Insufficiency, Chronic/drug therapy | 154 | 1.707116842 | 93 |
| 13 | Diabetic Nephropathies/therapy | 199 | 16.03588295 | 71 | 41 | Glomerular Filtration Rate | 164 | 6.622590065 | 79 |
| 14 | Kidney/drug effects | 476 | 11.09681988 | 76 | 42 | Biomarkers/blood | 126 | 2.42141366 | 83 |
| 15 | Diabetes Mellitus, Experimental/drug therapy | 401 | 5.41108036 | 80 | 43 | Renal Insufficiency, Chronic/epidemiology | 117 | 5.463775158 | 85 |
| 16 | Diabetic Nephropathies | 100 | 3.054833651 | 96 | 44 | Albuminuria/drug therapy | 137 | 3.159614563 | 88 |
| 17 | Diabetic Nephropathies/complications | 161 | 10.9369669 | 74 | 45 | Podocytes/drug effects | 90 | 2.380554914 | 83 |
| 18 | Hypoglycemic Agents/therapeutic use | 391 | 14.7321043 | 70 | 46 | Diabetes Mellitus, Type 2/urine | 121 | 6.479604244 | 77 |
| 19 | Diabetes Mellitus, Type 1/complications | 269 | 11.97052002 | 77 | 47 | Diabetes Mellitus, Type 2 | 63 | 1.609865546 | 96 |
| 20 | Diabetes Mellitus, Type 2/blood | 279 | 9.558413506 | 75 | 48 | Kidney Failure, Chronic/therapy | 74 | 0.748316169 | 93 |
| 21 | Diabetes Mellitus, Experimental/complications | 270 | 12.85853577 | 75 | 49 | Signal Transduction | 105 | 2.201956034 | 85 |
| 22 | Kidney/pathology | 278 | 20.10590553 | 67 | 50 | Diabetes Mellitus, Type 2/diagnosis | 136 | 1.499567509 | 84 |
| 23 | Kidney/metabolism | 256 | 14.14010525 | 71 | 51 | Glucose/metabolism | 87 | 5.031882763 | 79 |
| 24 | Podocytes/metabolism | 228 | 9.336707115 | 79 | 52 | Plant Extracts/pharmacology | 129 | 1.895391941 | 88 |
| 25 | Diabetic Nephropathies/urine | 178 | 9.577069283 | 74 | 53 | Polymorphism, Single Nucleotide | 90 | 0.402818322 | 96 |
| 26 | Kidney/physiopathology | 264 | 14.80787563 | 70 | 54 | Albuminuria/diagnosis | 133 | 3.04097867 | 83 |
| 27 | Diabetes Mellitus, Type 2/epidemiology | 249 | 8.595939636 | 76 | 55 | Mesangial Cells/metabolism | 85 | 0.789119542 | 90 |
| 28 | Diabetes Mellitus, Experimental/metabolism | 238 | 6.172931671 | 80 |