Fig. 3.

Immunofluorescent spectra of RNAPII detected in normal and ccRCC tumorous tissue parts. A) N represents non-tumorous tissue parts, while T corresponds to ccRCC sections. Representative images of RNAPII staining in peritumoral (left) and tumour tissues (right) from ccRCC patients. For the better visualization of the changes in RNAPII level, one cell is represented in a magnified resolution in each specimen. Scale bars represent 30 µm and 1.5 µm, respectively. B) The observed alterations in the quantification of relative fluorescence intensity (CTCF) of RNAPII level between the tumorous and non-tumorous tissue parts obtained from automated image acquisition (n=30) were illustrated in box plots and evaluated based on independent samples t-test, ***P < 0.001.