Figure 1.

Search strategy, analysis strategy, and results. A. Preferred Reporting Items for Systematic Reviews and Meta-Analyses flow diagram of search results, screening process, exclusion criteria, and final count of included studies. See methods for further information on “sham-not-saline” studies. B. Defined terminology and analysis strategy. C. Diagrams and metadata for the 9 behavioral tests included in this systematic review and meta-analysis: elevated plus/zero maze, open field test, light/dark box, place escape/avoidance paradigm, forced swim test, tail suspension test, sucrose preference test, wheel running, and burrowing. Main results include global summary effect estimates for all 9 tests and a subset of sub-group analysis and meta-regressions for the EPM/EZM, burrowing, and FST. Forest plots with individual experiments and studies, all sub-group analyses, and all meta-regressions per behavioral test are available in the supplemental file.