Table 1:

Clinicopathologic Features of GLI1-Altered Neoplasms in This Study

Case	Age/Sex	Location	IHC Positive	IHC Negative	Genetics	Clinical
1	49/F	Kidney	Cyclin D1, CD10, ER, Bcl2, SMA (weak)	S100, AE1/3, Cam5.2, CK903, EMA, PR, GCDFP, p63, HMB45, CD34, ALK	GLI1-FOXO4 fusion	History of breast cancer; NED 7 years
2	33/F	Kidney (renal pelvis)	Cyclin D1, CD10, Bcl2, Vimentin	S100, SMA, ER, BCOR, AE1/3, EMA, calponin, desmin, synaptophysin, p40, SOX10, CD34, HMB45	GLI1 fusion (partner not known)	NED 25 months
3	49/F	Uterus	Cyclin D1, CD10, ER (patchy), SMA	S100, PR, AE1/3, Cam5.2, EMA, HMB45, Melan A, CD117, pan-NTRK, ALK, calretinin	GLI1 amplification	Pelvic recurrence, brain metastasis, DOD 3 years
4	88/F	Uterus	Cyclin D1, CD10, BCOR, MDM2, desmin (focal)	S100, SMA, caldesmon, ER, PR, ALK, ROS	GLI1 amplification	Recent case

IHC= immunohistochemistry; DOD=dead of disease; NED=no evidence of disease