Table 4.
Weighteda estimates (95% confidence intervals) of brain MRI markersb (2011–2013) by carotid plaque status (1990–1992), ARIC-NCS
| Plaque Absent | Plaque Present | |
|---|---|---|
| (n=1322) | (n=473) | |
|
|
||
| Log2(WMH Volume) | ||
| Model 1 | Reference | 0.02 (−0.08, 0.12) |
| Model 2 | Reference | −0.01 (−0.10, 0.09) |
| Gray Matter Volume | ||
| Model 1 | Reference | −0.06 (−0.13, 0.02) |
| Model 2 | Reference | −0.05 (−0.12, 0.03) |
| Temporal-Parietal Meta ROI Cortical Volume c | ||
| Model 1 | Reference | −0.07 (−0.14, −0.003) |
| Model 2 | Reference | −0.06 (−0.13, 0.01) |
Inverse probability weighting was used.
Brain volume data is in SD units. Definition of 1-SD: log2(WMH) 1.28, deep gray matter 4.29 cm3, temporal-parietal meta ROI cortical volume 7.01 cm3.
Calculated as the combined volume of the parahippocampal, entorhinal, inferior parietal lobules, hippocampus, and precuneus regions.
Model 1: adjusted for age, sex, race/center, education, APOE ε4, total intracranial volume
Model 2: adjusted for model 1 plus body mass index, systolic blood pressure, smoking status, pack-years of smoking, antihypertensive medications, diabetes
Abbreviations: WMH = white matter hyperintensities; ROI = region of interest