Table 4:

Logistic regression analysis of Down syndrome as underlying cause of death, 2005–2017 US Multiple Cause of Death files excluding deaths with Alzheimer’s disease/Unspecified dementia, n=16,212

	OR	95% CI
Sociodemographic Characteristics
Age (ref: 18–29)
30–39	0.81*	(0.66, 0.99)
40–49	0.95	(0.79, 1.13)
50–59	0.94	(0.79, 1.12)
60–69	0.95	(0.79, 1.14)
70–103	0.56***	(0.44, 0.71)
Female	0.98	(0.91, 1.05)
Race-ethnicity (ref: White)
Black	1.24**	(1.09, 1.40)
Hispanic	1.16*	(1.01, 1.33)
Other	1.17	(0.90, 1.51)
Education (ref: 0–8 years)
9+ years	0.97	(0.89, 1.06)
Missing	1.00	(0.89, 1.12)
Comorbidities
Number of comorbidities (ref: 1)
2	0.43***	(0.39, 0.48)
3	0.23***	(0.21, 0.26)
4–13	0.09***	(0.08, 0.10)
Heart disease	0.88**	(0.81, 0.96)
Influenza/pneumonia	4.48***	(4.46, 4.94)
Pneumonitis	0.94	(0.85, 1.04)
Cerebrovascular diseases	0.37***	(0.31, 0.44)
Respiratory disease	1.73***	(1.57, 1.91)
Genitourinary diseases	0.97	(0.85, 1.10)
Congenital heart defect	1.55***	(1.31, 1.85)
Choking	1.04	(0.89, 1.22)
Malignant neoplasms	0.06***	(0.04, 0.09)
Non-specific conditions (R-code)	2.76***	(2.53, 3.01)
Cerebral palsy	0.52**	(0.34, 0.81)
Intellectual disability	1.64***	(1.40, 1.92)
Death context and processing
Place of death (ref: Hospital inpatient)
Hospital outpatient/ER/DOA	1.11	(0.96, 1.29)
Home	1.27***	(1.15, 1.41)
Nursing home	1.42***	(1.29, 1.57)
Other/Unknown	1.15*	(1.01, 1.32)
Autopsy (ref: No)
Yes	0.58***	(0.48, 0.70)
Unknown	1.09	(0.96, 1.25)
Year of death
2006	1.04	(0.87, 1.25)
2007	1.09	(0.91, 1.31)
2008	1.15	(0.96, 1.37)
2009	1.01	(0.85, 1.21)
2010	1.08	(0.90, 1.30)
2011	1.09	(0.91, 1.31)
2012	1.09	(0.91 1.31)
2013	1.22*	(1.02, 1.46)
2014	1.20	(1.00, 1.44)
2015	1.32**	(1.10, 1.58)
2016	1.31**	(1.09, 1.57)
2017	1.17	(0.98, 1.41)
Intercept	1.56**	(1.23, 1.98)

Note:

^*p < .05,

^**p < .01,

^***p < .001.

Bold text = predictor accounted for > 1% of variance in outcome, sr2>.01.