Table 3.
Association between variants related to atherosclerosis and ILAS status in NOMAS
| SNP | MAF | Genotype | OR | 95% CI | P-value |
|---|---|---|---|---|---|
| ADIPOQ rs2241767 | 0.22 | GG vs AA | 0.86 | 0.47-1.58 | 0.645 |
| AG vs AA | 1.03 | 0.13-8.16 | 0.696 | ||
| GG or AG vs AA | 0.87 | 0.49-1.57 | 0.658 | ||
| ADIPOQ rs182052 | 0.37 | AA vs GG | 1.08 | 0.66-1.79 | 0.721 |
| GA vs GG | 1.29 | 0.64-2.63 | 0.449 | ||
| AA or GA vs GG | 1.13 | 0.7-1.81 | 0.586 | ||
| APOE rs429358 | 0.09 | CC vs TT | 1.2 | 0.66-2.18 | 0.508 |
| TC vs TT | 2.42 | 0.5-11.87 | 0.255 | ||
| TT or TC vs TT | 1.27 | 0.72-2.25 | 0.364 | ||
| PDE4D rs2910829 | 0.52 | AA vs GG | 1.21 | 0.69-2.12 | 0.535 |
| GA vs GG | 0.69 | 0.34-1.43 | 0.289 | ||
| AA or GA vs GG | 1.04 | 0.6-1.79 | 0.438 | ||
| LPL rs320 | 0.28 | GG vs TT | 0.84 | 0.32-2.22 | 0.069 |
| TG vs TT | 1.68 | 1.05-2.71 | 0.002† | ||
| TG or GG vs TT | 1.52 | 0.96-2.41 | 0.047 | ||
| CYP11B2 rs1799998 | 0.37 | GG vs AA | 0.6 | 0.37-0.98 | 0.009 |
| AG vs AA | 0.42 | 0.18-0.97 | 0.013 | ||
| GG or AG vs AA | 0.56 | 0.35-0.89 | 0.001† |
Abbreviations: CI, confidence interval; OR, odds ratio.
Model is adjusted for sex, age, principal components, hypertension, diabetes, dyslipidemia, current smoking.
†
Statistically significant (Bonferroni corrected significance level is 0.003 [0.05/18]).