Table 4.
Genotypes distribution across race/ethnicity in NOMAS
| SNP | MAF | Genotype | NH White (n=154) |
Hispanic (n=771) |
NH Black (n=184) |
P-value |
|---|---|---|---|---|---|---|
| ADIPOQ rs2241767 | 0.22 | AA | 116 (75.3) | 602 (78.1) | 166 (90.2) | 0.002† |
| AG | 37 (24.0) | 157 (20.4) | 17 (9.2) | |||
| GG | 1 (0.6) | 12 (1.6) | 1 (0.5) | |||
| ADIPOQ rs182052 | 0.37 | GG | 65 (42.2) | 284 (36.8) | 89 (48.4) | 0.043 |
| GA | 73 (47.4) | 376 (48.8) | 73 (39.7) | |||
| AA | 16 (10.4) | 111 (14.4) | 22 (12.0) | |||
| APOE rs429358 | 0.09 | TT | 146 (94.8) | 691 (89.6) | 149 (81.0) | 0.001† |
| TC | 8 (5.2) | 79 (10.2) | 32 (17.4) | |||
| CC | 0 (0) | 1 (0.1) | 3 (1.6) | |||
| PDE4D rs2910829 | 0.52 | GG | 29 (18.8) | 183 (23.7) | 41 (22.3) | 0.214 |
| GA | 79 (51.3) | 378 (49.0) | 104 (56.5) | |||
| AA | 46 (29.9) | 210 (27.2) | 39 (21.2) | |||
| LPL rs320 | 0.28 | TT | 84 (54.5) | 412 (53.4) | 85 (46.2) | 0.110 |
| TG | 51 (33.1) | 299 (38.9) | 81 (44.0) | |||
| GG | 19 (12.3) | 60 (7.8) | 18 (9.8) | |||
| CYP11B2 rs1799998 | 0.37 | AA | 34 (22.1) | 317 (41.1) | 91 (49.5) | 0.001† |
| AG | 81 (52.6) | 354 (45.9) | 82 (44.6) | |||
| GG | 39 (25.3) | 100 (13.0) | 11 (6.0) |
Data are reported as number (%). Chi-squared test was used.
†
Statistically significant (Bonferroni corrected significance level is 0.008 [0.05/6]).