Table 5.
Correlation between 1-year changes in UMSARS and 1-year plasma NfL and volumetric brain MRI changes
| UMSARS-1 | UMSARS-2 | UMSARS total | |
|---|---|---|---|
| Plasma NfL |
r=0.564 p=0.05 |
r=0.795
P=0.002* |
r=0.739
P=0.006* |
| aSyn neuronal exosomes | r=0.196 p=0.50 |
r=0.173 p=0.55 |
r=0.200 p=0.49 |
| aSyn glial exosomes | r=0.148 p=0.61 |
r=0.139 p=0.63 |
r=0.155 p=0.59 |
| Whole brain |
r=−0.554
P=0.049* |
r=−0.591
P=0.033* |
r=−0.618
P=0.024* |
| Cerebellum |
r=0.238 P=0.58 |
r=0.269 P=0.42 |
r=0.297 P=0.31 |
| Right putamen |
r=−0.227 P=0.45 |
r=−0.145 P=0.63 |
r=−0.20 P=0.51 |
| Left putamen |
r=0.08 P=0.77 |
r=−0.316 P=0.29 |
r=−0.123 P=0.68 |
| Midbrain |
r=−0.140 P=0.64 |
r=0.267 P=0.37 |
r=0.067 P=0.82 |
| Pons |
r=−0.063 P=0.83 |
r=0.265 P=0.38 |
r=0.108 P=0.72 |
| Medulla oblongata |
r=−0.114 P=0.71 |
r=0.234 P=0.44 |
r=0.064 P=0.83 |
Pearson’s r was calculated using the 12 patients who had complete UMSARS, NfL and MRI data. Shown P values are corrected for multiple comparisons using the Bonferroni-Holm’s method. UMSARS: Unified MSA Rating Scale.