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. 2022 Jan 28;37(4):675–686. doi: 10.1002/jbmr.4501

Fig. 3.

Fig. 3

Improvement of the OI phenotype and ER stress levels in male Aga2 +/− mice treated with 4‐PBA. (A,B) Quantification of total body length and weight in WT and Aga2 +/− male mice treated with 4‐PBA or untreated controls, n = 9 (WT control), 15 (WT treated), 5 (Aga2 +/− control), 11 (Aga2 +/− treated). Two‐way ANOVAs were performed, *p < 0.05 was considered statistically significant. (C) Quantification of long‐bone fracture incidence in 4‐PBA treated and untreated 2‐month‐old male Aga2 +/− mice, n = 11 (untreated) and 17 (treated). Significance was determined by t test. (D–H) Representative western blot and quantification of relative protein levels in femoral lysates of WT and Aga2 +/− mice treated with 4‐PBA or untreated control animals. n = 4/per group. Quantifications are displayed with median and interquartile range. Two‐way ANOVAs were performed, *p < 0.05 was considered statistically significant. *p < 0.05, **p < 0.01, ***p < 0.001, ns = not significant.