Fig. 4.

4‐PBA treatment improves bone mineralization, trabecular bone formation, and bone strength in Aga2 ^+/− mice. (A–E) Trabecular and bone parameter quantification of 4‐PBA treated and untreated Aga2 ^+/− 2‐months‐old male mice. Bars represent median and interquartile range. n = 8. (F–H) Quantification of biomechanical analyses via three‐point‐bending in 4‐PBA‐treated and untreated Aga2 ^+/− 2‐month‐old male mice. Bars represent median and interquartile range. n = 8. Open circles correspond to the animals represented in I,J. Two‐way ANOVAs were performed, *p < 0.05 was considered statistically significant. *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001, ns = not significant. (I–L) Representative visual images of trabecular (top) and cortical bone (bottom) μCT analysis in 4‐PBA–treated and untreated Aga2 ^+/− mice.