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. Author manuscript; available in PMC: 2023 Apr 14.
Published in final edited form as: Cell. 2022 Mar 4;185(8):1346–1355.e15. doi: 10.1016/j.cell.2022.02.026

Figure 3. Cryo-EM structure of a TMEM106B doublet fibril.

Figure 3.

Cryo-EM mesh density (mesh) and atomic model (sticks) of (A) a TMEM106B doublet fibril and (B) the interface between the two protofilaments in the TMEM106B doublet mediated by a non-proteinaceous, anionic cofactor (purple mesh) that binds to the sidechains of residues K178 and R180 of each protofilament. See also Figure S5 and Table S2.