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. Author manuscript; available in PMC: 2022 Oct 15.
Published in final edited form as: Cancer Res. 2022 Apr 15;82(8):1518–1533. doi: 10.1158/0008-5472.CAN-21-1807

Figure 1. Transcriptome profiling of canonical Wnt/β-catenin signaling in PC cells.

Figure 1.

A, Differentially expressed genes between VCaP with (n=2) or without (n=2) WNT3a/RNF43 knockdown (p-value <0.05). B, Differentially expressed genes between VCaP with control siRNA (n=2) and APC siRNA (n=2) (p-value <0.05). C, Overlap of differentially expressed genes from the two treatments. D, Enriched pathways based on shared genes. E, Enriched pathways for genes regulated only by APC. Enrichment was by Metacore Pathway Enrichment Analysis, p<0.01. Blue stripes, enrichment for the common 124 genes; Orange solid bars, enrichment for genes uniquely regulated with RNF43i/WNT3a; blue solid bars, enrichment for genes uniquely regulated upon APC knockdown.