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. Author manuscript; available in PMC: 2022 Oct 15.
Published in final edited form as: Cancer Res. 2022 Apr 15;82(8):1518–1533. doi: 10.1158/0008-5472.CAN-21-1807

Figure 4. Wnt/β-catenin activity is correlated with tumor cell expression of WLS.

Figure 4.

A, Expression correlation between potential Wnt drivers and WNT activity in TCGA (n=448) dataset. B, Representative IHC of WLS in prostate. Upper left, normal prostate glands with magnified focus area. Upper right, PIN lesions (black dashed line circles a PIN focus, black arrows indicate luminal tumor cells; green arrows indicate basal cells; red circles and arrows indicate surrounding tumor foci and lack ok basal cells). Lower panels show WLS in primary PC, with heterogeneous WLS expression shown in lower right (tumor area with positive WLS staining indicated by a red arrow). C, Correlation between WLS mRNA and Wnt activity in FHCRC (n=149), WCPCDT (n=99) and SU2C (n=89) datasets. D, Representative IHC of WLS in a TMA of mCRPC (n=20), showing a range from negative to strong staining patterns. A and C statistics: Pearson correlations with linear regression, correlation scores (r) and p values are shown. Significant: P<0.05.