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. Author manuscript; available in PMC: 2022 Oct 15.
Published in final edited form as: Cancer Res. 2022 Apr 15;82(8):1518–1533. doi: 10.1158/0008-5472.CAN-21-1807

Figure 5. Downstream effectors of canonical Wnt/β-catenin signaling in PC.

Figure 5.

A, Random forest analysis intersecting genes most correlated with Wnt/β-catenin pathway activation in TCGA dataset and in VCaP cells with APC knockdown and RNF43i/WNT3a stimulation. B, qRT-PCR for downstream effectors of Wnt/β-catenin signaling in VCaP and RV1 cells with RNF43i/WNT3a stimulation (40 or 100 ng/ml) or APC knockdown. C, Immunoblotting of Wnt/β-catenin targets in VCaP (left panel) and RV1 (right panel) after RNF43i/WNT3a stimulation or APC knockdown (representative of at least 3 replicates).