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. Author manuscript; available in PMC: 2022 Oct 15.
Published in final edited form as: Cancer Res. 2022 Apr 15;82(8):1518–1533. doi: 10.1158/0008-5472.CAN-21-1807

Figure 6. WLS association with canonical versus noncanonical Wnt signaling in mCRPC.

Figure 6.

A, Plot comparing for all genes their correlation with WLS expression versus WNT47 signature using the corresponding correlation coefficients (WLS_CE and WNT47_CE). The correlations were assessed for TCGA, FHCRC, WCPCDT and SU2C datasets. B, Left panel, overlap of the top thousand genes correlating with WLS expression and not the WNT47 signature in mCRPC datasets: FHCRC, WCPCDT and SU2C. Right panel, common five potential noncanonical effectors and their corresponding correlation coefficients with WLS. C, WNT5A across a panel of PC cell lines by both RT-qPCR and immunoblotting. D, RT-qPCR quantification of the five potential noncanonical effectors in response to WNT5a stimulation in LAPC4 and VCaP. E, Distribution of WLS from scRNA-seq analysis of mCRPC tumor biopsies and its association with Wnt activity defined by WNT47 signature. F, Scatter plots with lines at median and interquartile ranges of Wnt activity between ENZ-naïve (n=337) and ENZ-exposed (n=139) cells from scRNA-seq dataset.