Table 1.
Patient Characteristics by ACLF Grade
| ACLF Classification by UNOS | |||||
|---|---|---|---|---|---|
|
| |||||
| Total (N=481) | None (N=250) | Grade 1 (N=75) | Grade 2 (N=79) | Grade 3 (N=77) | |
| Characteristics | |||||
|
| |||||
| Male, n (%) | 280 (58) | 147 (59) | 44 (59) | 47 (60) | 42 (54) |
|
| |||||
| Age, median (IQR) | 55 (48–61) | 56 (48–61) | 57 (49–62) | 55 (47–61) | 53 (46–60) |
|
| |||||
| Non-Hispanic White, n (%) | 247 (51) | 143 (57) | 39 (52) | 32 (40) | 33 (43) |
|
| |||||
| Primary Listing Diagnosis, n (%) | |||||
| Alcohol | 155 (32) | 71 (28) | 27 (36) | 27 (34) | 30 (39) |
| NASH/Cryptogenic | 103 (21) | 46 (18) | 21 (28) | 22 (28) | 14 (18) |
| HBV/HCV | 118 (24) | 65 (26) | 16 (21) | 19 (24) | 18 (23) |
| AIH/PBC/PSC | 69 (14) | 44 (18) | 7 (9) | 7 (9) | 11 (14) |
| Other | 36 (7) | 24 (10) | 4 (5) | 4 (5) | 4 (5) |
|
| |||||
| Alcohol-Associated Hepatitis by NIAAA Criteria, n (%) | 19 (4) | 7 (3) | 5 (7) | 3 (4) | 4 (5) |
|
| |||||
| Primary Insurance, n (%) | |||||
| Private | 163 (34) | 81 (32) | 31 (41) | 30 (38) | 21 (27) |
| Medicare | 157 (33) | 89 (36) | 24 (32) | 23 (29) | 21 (27) |
| Medicaid | 161 (33) | 80 (32) | 20 (27) | 26 (33) | 35 (45) |
|
| |||||
| Hospitalized, n (%) | 218 (45) | 39 (16) | 42 (56) | 64 (81) | 73 (95) |
|
| |||||
| In Intensive Care Unit, n (%) | 135 (28) | 9 (4) | 16 (21) | 41 (53) | 69 (90) |
|
| |||||
| Diabetes, n (%) | 131 (27) | 53 (21) | 36 (48) | 22 (28) | 20 (26) |
|
| |||||
| MELD-Na score, median (IQR) | 23 (16–34) | 16 (14–20) | 28 (22–33) | 35 (31–39) | 43 (40–45) |
|
| |||||
| Organ Failures | |||||
|
| |||||
| Liver | 145 (30) | 9 (4) | 19 (25) | 48 (61) | 69 (90) |
|
| |||||
| Coagulation | 127 (26) | 2 (1) | 10 (13) | 45 (57) | 70 (91) |
|
| |||||
| Kidney | 167 (35) | 0 (0) | 44 (59) | 49 (62) | 74 (96) |
|
| |||||
| Brain | 51 (11) | 8 (3) | 2 (3) | 16 (20) | 25 (32) |
|
| |||||
| Respiratory | 19 (4) | 0 (0) | 0 (0) | 0 (0) | 19 (25) |
|
| |||||
| Circulatory | 21 (4) | 0 (0) | 0 (0) | 0 (0) | 21 (27) |