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. Author manuscript; available in PMC: 2022 Oct 1.
Published in final edited form as: Nat Struct Mol Biol. 2022 Mar 24;29(4):292–305. doi: 10.1038/s41594-022-00745-3

Extended Data Fig. 3. DOPEGAL modification at Tau K353 is dependent on NE.

Extended Data Fig. 3

Tau P301S/DBH+/− and Tau P301S/DBH−/− mice of 3 months and 9 months old were examined for DOPEGAL modification and phosphorylation of Tau in the LC by immunofluorescence staining. A. Representative images of DBH (green), Tau K353-DOPEGAL (red), and DAPI (blue), AT8 (green), Tau K353-DOPEGAL (red), and DAPI (blue) staining in LC sections of Tau P301S/DBH+/− and Tau P301S/DBH−/− mice. Scale bar = 100 μm. B. Quantification of Tau K353-DOPEGAL/AT8+ cells. Data are shown as mean ± SEM. n = 6 per group. Two-way ANOVA with Sidak’s multiple comparison.