Table 3.
Changes in cognitive function/behaviour and quality of life at treatment end (assessment performed at week 25) and end of follow-up in the evaluable population
| Parameter | Baseline (n = 13) | Week 25 (n = 11) | Week 48 (n = 10) | ||
|---|---|---|---|---|---|
| Change from baseline | p value | Change from baseline | p value | ||
| ALS-CBS | |||||
| Behaviour status score, median (IQR) | 41.0 (38.0, 42.0) | 0.0 (− 3.0, 2.0) | 0.7031 | − 1.0 (− 6.0, 1.0) | 0.2158 |
| Current symptom status score, median (IQR) | 3.0 (2.0, 4.0) | 0.0 (− 1.0, 1.0) | 0.7560 | 0.0 (− 1.0, 1.0) | 0.8281 |
| Cognitive screening score, median (IQR) | 17.0 (16.0, 18.0) | 0.0 (− 2.0, 1.0) | 0.8897 | − 1.0 (− 3.0, 2.0) | 0.3635 |
| ALSAQ-40 | |||||
| Physical mobility, median (IQR) | 20.0 (12.5, 70.0) | 10.0 (0.0, 20.0) | 0.0391 | 32.5 (7.5, 50.0) | 0.0015 |
| Independence, median (IQR) | 37.5 (20.0, 67.5) | 12.5 (− 2.5, 45.0) | 0.0413 | 25.0 (7.5, 45.0) | 0.0048 |
| Eating/drinking, median (IQR) | 0.0 (0.0, 16.7) | 0.0 (0.0, 25.0) | 0.0625 | 8.3 (0.0, 58.3) | 0.0313 |
| Communication, median (IQR) | 42.9 (0.0, 57.1) | 0.0 (0.0, 28.6) | 0.1250 | 0.0 (0.0, 35.7) | 0.0625 |
| Emotional functioning, median (IQR) | 25.0 (20.0, 32.5) | 5.0 (− 2.5, 22.5) | 0.0617 | 7.5 (0.0, 20.0) | 0.0767 |
p-values in bold stands for p < 0.05
ALSAQ-40, Amyotrophic Lateral Sclerosis Assessment Questionnaire 40; ALS-CBS, Amyotrophic Lateral Sclerosis-Cognitive Behavioral Screen; IQR, interquartile range