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. 2022 Apr 19;13:2144. doi: 10.1038/s41467-022-29794-4

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — Heatmap of gene expression of 43 patient-derived xenograft (PDX) samples for the selected gene signatures; neuroendocrine (NE) vs. non-NE gene signature³² (a), genes crucial in SCLC (b), EMT gene signature (c), MYC family gene expression (d), and metabolic gene signature⁴² (e). Color-coded panel on top depicts treatment status (naïve or treated) and subtype annotation based on IHC. Source data are provided as a Source Data file. f H&E and immunohistochemistry image for POU2F3 are shown for the clinical MSK773. Scale bar as indicated, 20 μM. g Genomic landscape in MSK773A (adenocarcinoma) vs. MSK773A (SCLC) samples representing putative driver alterations (i.e. excludes variants of unknown significance) in altered genes as detected by MSK-IMPACT²⁰ targeted next-generation sequencing assay.