Table 2.
Weights and significance of covariance between the expression of individual genes of interest and [11C]flumazenil signal.
| Gene | PLS rank/15,633 | PLS gene weight (Z-score) | pFDR |
|---|---|---|---|
| GABRB2 | 22 | 6.91 | 1.45 × 10−9 |
| GABRD | 227 | 5.64 | 3.95 × 10−7 |
| GABRG3 | 392 | 5.11 | 3.97 × 10−6 |
| GABRA1 | 401 | 5.07 | 4.67 × 10−6 |
| GABRG2 | 597 | 4.67 | 2.31 × 10−-5 |
| GABRA4 | 2101 | 2.94 | 6.43 × 10−3 |
| GAD1 | 2405 | 2.70 | 0.0117 |
| VIP | 2566 | 2.60 | 0.0150 |
| CCK | 3050 | 2.26 | 0.0311 |
| PVALB | 3059 | 2.26 | 0.0315 |
| GABRA3 | 12,482 | −2.09 | 0.0436 |
| GABRG1 | 12,816 | −2.29 | 0.0293 |
| CALB1 | 13,166 | −2.50 | 0.0190 |
| NOS1 | 13,727 | −2.91 | 6.70 × 10−3 |
| CALB2 | 15,393 | −5.09 | 4.34 × 10−6 |
Statistically significant results (pFDR < 0.05) shown only. PLS weight and pFDR shown to third significant figure. PLS, partial least squares regression analysis. CALB1, calbindin, CALB2, calretinin, CCK, cholecystokinin, GABRA1/3/4, GABAAR receptor subunits α1/3/4, GABRB2, GABAAR receptor subunit β2, GABRD, GABAAR receptor subunit δ, GABRG1-3, GABAAR receptor subunits γ1-3, GAD1, GABA-synthesising enzyme GAD67, NOS1, neuronal nitric oxide synthase, PVALB, parvalbumin, VIP, vasoactive intestinal peptide.