Fig. 8. Proposed combined endolysin antibiotic therapeutic: The presence of recalcitrant biofilms typically mean that front line antibiotics are infective when treating G. vaginalis associated BV (right).

Here we suggest that the lytic activity of phage endolysins leads to biofilm disruption and increased activity of front-line antibiotics (left) potentially leading to greater effective clearance and lower recurrence rates. Figure created using BioRender.