Fig. 6. Unique transcriptomic priming supports a in vivo balanced multilineage output of EPCR⁺ HSCs.

a In vivo human myeloid (CD33⁺) vs B lymphoid (CD19⁺) differentiation outputs of EPCR⁺, CD90⁺EPCR^- and MPP cells in 1^ry NSG mice at 12 wks post transplanted with the indicated cell doses (n = 7–11 mice); mean lines are shown. b Denoted lineage-priming gene modules^8,9 enriched in EPCR⁺ HSCs, CD90⁺EPCR⁻ progenitors, and MPPs; NES, normalized enrichment scores enriched (FDR p-value *<0.1 and **< 0.05 by pre-ranked Gene Set Enrichment Analysis, GSEA; p-values were adjusted using Benjamini–Hochberg method) are shown. c Heatmap of DE genes (padj <0.05 and with cut-off of log₂FC ± 0.4, see Supplementary Data 4) between EPCR⁺ vs EPCR^-CD90⁺ vs MPP found in the enriched lineage-priming gene modules shown in (b). The scale represents log₂ of normalized transcript expression values. Source data are provided as a Source Data file.