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. 2022 Apr 19;13:2054. doi: 10.1038/s41467-022-29695-6

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — a The CAESAR-imputed contact map of K562 at MYC region (chr8: 127,600,000–127,850,000) demonstrates significant contacts between MYC and PVT1, which agree with CRISPRi score peaks, but are not shown on the original input Hi-C contact map. The magnitude of the epigenomic features is the observed value divided by the genome-wide average. b The CAESAR-imputed contact map of K562 at GATA1 region (chrX: 48,725,000–48,825,000) demonstrates significant contacts between GATA1 and HDAC6, which agree with CRISPRi score peaks, but are not shown on the original input Hi-C contact map.