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. 2022 Apr 19;12:6422. doi: 10.1038/s41598-022-09361-z

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Preventive exercise training attenuates hemodynamic and sympathovagal imbalance induced by doxorubicin. (A) SBP: systolic blood pressure (mmHg); (B) DBP: diastolic blood pressure (mmHg); (C) Heart rate (bpm); (D) HRV: heart rate variability (ms²); (E) LF/HF ratio: low frequency/high frequency ratio as sympathovagal balance; (F) LF: low frequency representative of sympathetic component (Hz); (G) HF: high frequency representative of parasympathetic component (Hz). C: control (for hemodynamic parameters: n = 8; for sympathovagal parameters: n = 5); D: doxorubicin-treated (n = 8); CT: control-trained (for hemodynamic parameters: n = 10; for sympathovagal parameters: n = 7); DT: doxorubicin-trained (for hemodynamic parameters: n = 7; for sympathovagal parameters: n = 5). One-way ANOVA and Tukey’s post-hoc. *p < 0.05, **p < 0.01 above error bars in comparison to control group.