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. 2022 Apr 19;12:6445. doi: 10.1038/s41598-022-09497-y

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Knockdown of USP32 inhibits cell metastasis. (A) Transwell migration assay showing that silencing USP32 suppressed cell migration. Bar: 10 μm. Images were representatives of three independent experiments. (B) Statistical quantification of (A). (C) Matrigel invasion assay showing that USP32 deficiency suppressed cell invasion. Bar: 10 μm. Images were representatives of three independent experiments. (D) Statistical quantification of (C). One way ANOVA followed by Tukey’s post-hoc test: vs siRNA NC, **p < 0.01, ***p < 0.001, ****p < 0.0001.