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. 2022 Apr 19;8:209. doi: 10.1038/s41420-022-01002-8

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 9 — A T2-Weighted MRI and X-ray of a rat tail at 4th and 8th week after surgery (arrow: location of the needle-puncture disc). B The Pfirrmann MRI grade scores of the three groups at 4th and 8th week after surgery (six rats at each time point for each group). C The disc height index (DHI) was determined in the three groups at 4th and 8th week after surgery (six rats at each time point for each group). D Representative HE staining and S-O staining of punctured discs in different groups. Three sections were randomly selected for quantification, with a representative example shown. E The histological grades were evaluated at 4th and 8th week post-surgery in the three groups (six rats per group). F The expression of Nrf2 and NLRP3 was assessed by immunohistochemistry staining of intervertebral disc sections in the different groups. G Relative positive cells of Nrf2, TXNIP and NLRP3 were quantified by Image J. All data are presented as mean ± standard deviation (SD); *P < 0.05, **P < 0.01.