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. 2022 Apr 19;13:2143. doi: 10.1038/s41467-022-29780-w

Fig. 3. Boronsome is an efficient platform for boron and chemotherapy drug delivery.

Fig. 3

a Schematic illustration of chemotherapeutic agents encapsulated carboranyl-lipid boronsomes. b Representative TEM images of boronsomes. Three independent experiments were performed and representative results are shown. Scale bar, 50 nm. c-e Dynamic light scattering size c, PDI d and zeta potential e of liposomes, boronsomes and Dox-boronsomes (n = 3). f Boronsomal stability in 50% FBS. The size and PDI (n = 3) were measured at different time points. g Boron concentration (n = 4) of 4T1 cells after incubation with various concentrations of boronsome for 24 h. h Boron concentration (n = 4) of 4T1 cells after incubation with FBY, BPA and boronsomes for 24 h at the same boron dose (two-tailed unpaired Student’s t test, FBY vs Boronsome: **p = 0.0027, BPA vs Boronsome: **p = 0.0040). i Survival fraction (n = 6) of 4T1 cells under various concentrations of boronsome after 24 h. Data are means ± SEM. Source data are provided as a Source Data file.