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. 2022 Apr 19;13:2042. doi: 10.1038/s41467-022-29625-6

Fig. 7. Graphical summary.

Fig. 7

Our data support a model in which a non-coding, germline 5 bp deletion activates a set of long-range enhancers by creating a de novo MEF2 TF motif, which in turn triggers AXIN2 expression. MEF2 presence correlates with long-range TF nucleation and chromatin compaction, suggesting that these phenomena are major drivers of AXIN2 VCM formation. In addition, this 5 bp deletion and AXIN2 expression are associated with reduced CLL predisposition and disease progression.