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. 2022 Apr 19;13:2070. doi: 10.1038/s41467-022-29684-9

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — a Schematic overview of ABP experiment performed in PDAC organoids, created with BioRender.com. b In-gel visualization of Cy5-Ub-ABP labeled DUBs in patient-derived organoids (PDO). c Mass spectrometry analysis of DUBs labeled with Biotin-ubiquitin-ABP in PDOs. Volcano blot depicts the label-free quantification (LFQ) of −log₁₀ t-test p-value vs ratio difference of untreated (right side) and DUBi-treated (left side) samples. Gray dots indicate all proteins identified, and red dots highlight all significant DUBs. d Venn diagram summarizing identified DUBs, from mass spectrometry experiments comparing untreated vs DUBi-treated samples. Source data are provided as a Source Date file.