Table 4.

Prevalence and odds ratio of constipation in patients with colorectal cancer and siblings

Group	N exposed (% with constipation)		Odds ratio* (95%CI)	Odds ratio** (95%CI)
	CRC with constipation	Comparators with constipation
Overall	1 254 (7.0%)	2 468 (6.6%)	1.05 (0.97–1.13)	1.04 (0.97–1.13)
Sex
Female	736 (9.2%)	1 511 (8.2%)	1.04 (0.91–1.18)	1.03 (0.91–1.18)
Male	518 (5.3%)	957 (5.0%)	1.06 (0.92–1.23)	1.07 (0.92–1.24)
Age
18y – <30y	4 (7.7%)	0	-	-
30y – <40y	5 (1.8%)	6 (1.1%)	0.65 (0.06–6.60)	0.65 (0.06–6.61)
40y – <50y	30 (3.1%)	54 (2.1%)	1.70 (0.86–3.37)	1.70 (0.86–3.38)
50y – <60y	104 (3.7%)	240 (3.2%)	1.15 (0.82–1.60)	1.17 (0.83–1.64)
60y – <70y	417 (6.0%)	884 (5.8%)	1.10 (0.93–1.29)	1.11 (0.94–1.31)
≥70y	694 (10.3%)	1 284 (11.1%)	0.90 (0.80–1.01)	0.89 (0.79–1.00)
Country of birth
Nordic country	1 239 (7.0%)	2 448 (6.6%)	1.04 (0.97–1.13)	1.04 (0.97–1.12)
Other	15 (9.2%)	20 (6.3%)	1.12 (0.49–2.58)	1.11 (0.48–2.55)
Level of education
≤9 years	401 (7.2%)	890 (7.3%)	0.89 (0.75–1.05)	0.89 (0.75–1.05)
10–12 years	533 (7.1%)	1 014 (6.3%)	1.24 (1.07–1.45)	1.24 (1.07–1.45)
>12 years	311 (6.7%)	543 (6.1%)	1.11 (0.90–1.36)	1.11 (0.90–1.36)
Year of colon cancer/Index year
July 2007–2010	221 (3.6%)	411 (3.1%)	1.14 (0.95–1.36)	1.14 (0.95–1.36)
2011–2013	478 (7.8%)	882 (6.9%)	1.14 (1.00–1.29)	1.13 (1.00–1.28)
2014–2016	555 (9.9%)	1 175 (10.2%)	0.94 (0.84–1.06)	0.94 (0.84–1.06)
Disease history within 5 years before index date, no. (%)
Cardiovascular disease (CVD)	705 (10.7%)	1 169 (13.6%)	0.78 (0.67–0.90)	0.78 (0.67–0.91)
Cancer (excluding CRC)	363 (9.1%)	518 (13.7%)	0.70 (0.51–0.95)	0.70 (0.51–0.95)
Diabetes	222 (11.7%)	300 (14.4%)	1.18 (0.80–1.75)	1.17 (0.79–1.74)
Neurologic disease	305 (16.1%)	581 (17.6%)	0.85 (0.58–1.25)	0.85 (0.57–1.26)
None of the above	328 (4.0%)	867 (3.5%)	1.13 (0.95–1.34)	1.10 (0.93–1.31)

CRC, colorectal cancer.

^*Conditioned on matching set (family);

^**Conditioned on matching set and further adjusted for education